As one of the most innovative restaurants in San Diego, we are committed to changing the way our guests think about food. Everything we do is made from scratch and with love, which is one of the many reasons we are referred to as Nature's Kitchen
From our yeast-free signature breads to our fruit-infused sangrias, something is always cooking in Cafe 21. Committed to sustainability and a true farm-to-table experience, we work with the best ingredients from locally grown produce, hormone-free grass fed meat, wild seafood, and antibiotic free Mary's chicken. With an eclectic and unique menu offering, we accommodate all dietary restrictions ranging from gluten-free, vegetarian, and vegan.
Let us connect you with all the beauty that our earth provides and awaken your palette with our superior food artistry and handcrafted cocktails. Be ready to experience Nature's Kitchen as interpreted by our revered and most inventive Chef Leyla.
With unrivaled decor and ambience, you can't help but be enchanted by the charm that surrounds you at Cafe 21. From either Gaslamp or University Heights, your next event will be unique and unforgettable, with an alluring atmosphere where old world meets new.
Cafe 21 Gaslamp: Situated in the heart of the famed Gaslamp Quarter, Cafe 21 is within walking distance of most major hotels as well as the San Diego Convention Center.
Cafe 21 University Heights: A mere 15 minutes from downtown San Diego, Cafe 21 University Heights is conveniently located off both the 8 and 163 Freeways and is easily accessible. Being just off the main street of Adams Avenue, you can't get any more local San Diego than this vibrant neighborhood.
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